Give this one points for originality: This gross-out comedy is a weird mashup of buddy-cop movies, Fantastic Voyage and Innerspace. The Farrelly brothers directed the live-action portion of the movie, about a slob named Frank (Bill Murray) whose disgusting lack of personal hygiene leads him to contract a deadly virus. Inside Frank’s body, his organs are rendered as a cartoon city, where Osmosis Jones (Chris Rock) is a streetwise cop, a white blood cell trying to keep Frank disease-free. When the deadly Thrax (Laurence Fishburne) comes to town and wreaks havoc, Jones must partner with Drix, an uptight medicine capsule (David Hyde Pierce), to save Frank from a threat that no other antibodies even want to acknowledge.
Rock is a stellar comedian who’s made a lot of inexplicably lame movies, so this one (along with the Madagascar cartoons) is easily one of his best. Hyde Pierce, who can’t help sounding like Niles Crane, has surprisingly good chemistry with Rock. As animated by Tom Sito and Piet Kroon, they’re a clever, inventive, colorful pair.
[youtube=http://www.youtube.com/watch?v=usQYXVAfTCw]