Released: Aug. 10, 2001
Budget: $75 million (estimated)
Domestic Opening Weekend: $5,271,248
Domestic Gross: $13,596,911
How’s this for an evening’s entertainment: watching cartoon germs and human cells do battle inside the body of a fat, ill zookeeper played by Bill Murray? It didn’t appeal much to other people, either, and Osmosis Jones belly-flopped in 2001. Despite its moderately revolting plot, however, the half-animated, half-live-action film actually garnered decent reviews (the New York Times called Murray “heroic in his willingness to sacrifice dignity and even humanity to get a laugh.”) The film also boasted a high-powered cast, including Chris Rock, David Hyde Pierce and Ron Howard (in person or in voice). But the movie just didn’t cough up at the box office: the $75 million flick took in just $14 million in theaters.